Abstract
The definition of the different types of neoplasias arising
from haematopoietic cells as given by the who classification in 2001, are
summarized: myeloid neoplasias comprising chronic myeloproliferative syndromes,
myelodysplasic syndromes, an intermediate group called chronic
myeloproliferative myelodisplasic syndromes, acute myeloid Leukaemia, lymphoid
neoplasias comprising Hodgkin's and non-hodgking's lymphomas, either B or NK/T,
histiocytic and dendritic cells neoplasias and finally mastocytosis.
The different entities of each type are mentioned as well as,
for the lymphomas, their frequency. This Classification recommends a
multidisciplinary approach for the diagnosis of each entity, comparing clinical
and biological data, the results of cytological, histopathological and
immunophenotypical studies as well as cytogenetic and molecular biology. In the
future, comparative studies will be easier, due to the international use of
this common language.
Key words:
Chronic myeloproliferative syndromes, Myelodysplasic
syndrome, acute myeloide leukaema, Hodgkin's lymphoma, non Hodgkin's lymphoma B
or NK/T, histiocytic and dendritic cell neoplasias, mastocytosis.
ABR~3IA(IONS
ADN : Acide Désoxyribonucléique.
BCL2: B Cell Leukemia.
BCR: Breakpoint Cluster Region. BH:
BCL2 Homology domain.
CEP110: Centrosome Protein 110. CFU:
Colony-Forming Unit.
CHU : Centre Hospitalo Universitaire. CMV:
CytomégaloVirus.
CRK: CT10 Regulator of Kinase. EBV :
Epstein Bar Virus.
EDS III : Enquête Démographique et de
Santé III. FAB : Franco Américano Britanique.
FGF: Fibroblast Growth Factor.
FGFR: Fibroblast Growth Factor
Receptor. FIM: Fused In Myeloproliferative disorder.
FISH: Fluorescent in situ hybridation.
FOP: Fused Oncogene Partner. FRS2:
FGF Receptor Substrate 2. FSC: Fibrosarcome
Congénital.
GP+E: Gag Pol + Env.
GRB2: Growth factor Receptor-Bound protein
2. HERV: Human Endogenous Retrovirus.
HHV8: Human Herpes Virus 8.
HTLV: Human T lymphocyte Virus. HTLV1: Human T
lymphocyte Virus 1. HTLV2: Human T lymphocyte Virus 2. Ig :
Immunoglobuline.
IL-3 : Interleukine 3.
JM : domaine Juxta-Membranaire.
Kb: Kilobase (un millier de paires de bases). LA :
Leucémie Aiguë.
LAL : Leucémie Aiguë Lymphoblastique. LAM
: Leucémie Aiguë Myéloïde.
LBL : Lymphome Lymphoblastique. LDH
: Lactico Déshydrogénase.
LLC : Leucémie Lymphoïde Chronique. LMC :
Leucémie Myéloïde Chronique.
LMNH : Lymphome Malin Non Hodgkinnien. LNH: Lymphome
Non Hodgkinnien.
LTR: Long Terminal Repeat.
MAPK: Mitogen Activated Protein Kinase.
Mb: Milibase (un million de paires de bases). MDH : Maladie De
Hodgkin.
Méga rades:2.5 1000000 tours.
MFI: Myélofibrose Idiopathique.
MM : Myélome multiple.
MOPP : Moutarde à l'azote, Oncovin,
Procarbamazine, Prednisone.
MOZ: Monocytic Leukemia Zinc Finger.
MSCV: Murine Stem Cell Virus.
MTOR: mamalian Target of Rapamycin.
NFS: Numération Formule Sanguine.
OMS : Organisation Mondiale de la Santé.
PH: Plekstrin Homology domain.
PHA: Potentiel hydrogène.
PI3K: Phosphatidylinositol-3'OH Kinase.
PLCã: Phospholipase C gamma.
PTB: PhosphoTyrosine Binding domain. PV:
Polyglobulie de Vaquez.
RPMI: Le Roswell Park Mémorial lnstitute
médium est un milieu utilisé en culture. RTK :
Récepteur à activité tyrosine Kinase.
SCF: Stem Cell Factor.
SH2: Src Homology 2.
SHC: SH2-containing sequence ou Src
Homologous and Collagen.
SHIP: SH2 containing inositol
phosphatase. SIDA : Syndrome d'Immuno Déficience Acquise. SM
: Splénomégalie Myéloïde.
SMC : Splénomégalie
Myéloïde Chronique. SMD : Syndrome
Myélodysplasique.
SMP : Syndrome
Myéloprolifératif.
SNC : Système Nerveux
Central.
SOS: Son On Sevenless.
STAT: Signal Transducer and Activator of
Transcription.
SVP: Sérum de veau foetal.
TE : Thrombocytopénie
Essentielle. TE : Trombocytémie
Essentielle.
TK: Domaine Tyrosine Kinase.
TM: Domaine Transmembranaire.
USA: United States of America.
Vaquez : Maladie de Vaquez.
VHB : Hépatite Virale B.
VHC : Hépatite Virale C.
VIH : Virus de l'Immunodéficience Humaine.
Waldenström : Maladie de Waldenström.
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