I.3 Objectives
Main objective
Since there are no reports about the quality of
pharmaceuticals in Rwanda, this study was undertaken to evaluate the quality of
some essential drugs marketed in Rwanda. The main objective of this study is to
assess the quality of some essential drugs available on the Rwandan market
through the USP 24 requirements. Furthermore to check their stability under
simulated tropical conditions of the IVth climatic zone (40C and
75%RH).
Specific objectives
· Determination of the drug content
· Determination of the in vitro drug dissolution
· Evaluation of the impact of accelerated stability
testing (storage at 40°C, 75 % RH) on drug content and in vitro
dissolution.
According to this study an acceptable
formulation complies with the USP 24 specifications with the respect to the
dissolution and amount of active ingredients. A stable product is defined as a
product which shows no significant degradation or change in its physical and
chemical properties and remains within the labelled specifications.
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