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GHENT UNIVERSITY
FACULTY OF PHARMACEUTICAL SCIENCES
LABORATORY OF PHARMACEUTICAL TECHNOLOGY
___________________________
Academic year 2002-2003
AN IN VITRO STUDY OF THE QUALITY OF ESSENTIAL DRUGS
AVAILABLE ON THE RWANDAN MARKET
Thesis submitted to Ghent University, Belgium, in partial
fulfilment of the
requirements for the degree of Master in Pharmaceutical
Sciences (M. Pharm)
By
Pierre Claver KAYUMBA (B.
Pharm.)
Faculty of Sciences and Technology, Department of Pharmacy,
National University of Rwanda, Butare-Rwanda.
Promoters:
Prof. Dr. Apr. J.P. REMON
Prof. Dr. Apr. C. VERVAET
This work is dedicated to my lovely wife Verdiane and to
our beloved children Audrey, Gabin and Jean Marc, for their love, patience,
understanding and care.
Acknowledgements
At the end of this thesis, I would like to express my
gratitude to the government of Rwanda (GOR) for the provision of a scholarship
to support my studies in Belgium.
I wish to thank Prof.Dr. J.P. Remon, for accepting me in
his laboratory and promoting this work. His encouragement, inspiration and
moral support were very important in the accomplishment of this work.
I am also grateful to Prof.Dr. C. Vervaet for his advice
and support towards the realisation of this work.
My appreciation goes to Prof.Dr. W. Baeyens and Prof.Dr.
J. Demeester for their lectures, which were very useful in my research
work.
Thanks to Pharm. D. Ameye for his guidance and assistance
in the various analytical methods.
I am grateful to Dr. J.D. Ntawukuliryayo for his advice,
kindness and sympathy in carrying out my study.
My gratitude goes to Pharm. E. Bienvenu for his critical
comments, which contributed to the final form of this thesis.
My sincere thanks to the Laboratory of Pharmaceutical
Technology for their hospitality and support. Especially, I thank D. Tensy, M.
De Meyer, K. Wullaert, and B. Vandenbussche for their invaluable
assistance.
I wish to thank my colleagues, master students A. Dukic,
A. Eltraplsi and K. W. Mwamwitwa for their useful moral and technical support,
advices and suggestions in the realisation of this work.
I extend special thanks to my wife Verdiane, my daughter
Audrey, my sons Gabin and Jean Marc, for their love, courage, patience and
understanding that made ever possible the realisation of this work.
Thanks to all Rwandan people resident in Ghent or
Brussels, who have contributed to this thesis in many different ways.
Pierre Claver KAYUMBA
September, 2003
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