Interaction of quinolines and artemisinin based antimalarials drugs with ferriprotoporphyrin IX

HRP-2

Target of new drug discovery

strategy

Drug transport to parasite cytosol carrier mediated transport

(pH 4.7-5.4)

Drugs acumulation to millimole level in food vacuole by weak base mechanism

Parasite membrane

Red cell membrane

Drug uptake through biological membrane by passive diffusion phenomena

Blood schizontocidal antimalarials