Evaluation of the hypoglycemic, hypolipidemic and anti alpha amylase effects of extracts of the twigs and fruits of ficus ovata vahl (moraceae)

CONCLUSION

In conclusion, the results from this study whose objective was to evaluate the antihyperglycemic, hypoglycemic, antihyperlipidemic and in vitro anti á-amylase properties of twigs and fruits extracts of Ficus ovata showed that, firstly hydroethanolic fruits and twigs were the most active extracts due to their high antioxidant and antiamylase activities. Moreover, the acute toxicity study showed that FOHT and FOHF were weakly toxic since no death was recorded at the experimental dosage of 5000mg/kg BW. In addition, acute hypoglycemic and antihyperglycemic studies revealed that hydroethanolic twigs extract was most active compared to the fruits extracts. Finally the sub acute preventive study showed that the hydroethanolic fruit extract was most active in ameliorating the rise in blood lipids and glucose levels induced by the high fructose high cholesterol diet.

These results suggest that hydroethanolic extracts of Ficus ovata twigs and fruits could be of interest in the prevention of hyperlipidemia and hyperglycemia associated to type 2 diabetes

PESPECTIVES

To pursue these studies on F. ovata, we are proposing the following:

· Repeat this preventive study for a long period of about 3 months;

· determination of precise active substance(s), site(s) and mechanism(s) of its pharmacological effect;

· Evaluation of antidiabetic activity on streptozotocin induced diabetic models;

· Evaluation of the sub acute, Chronic and theragenic toxicity of our plant.

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